This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will measure the neurochemical profile of the cerebellum and the brainstem in patients with genetic and sporadic spinocerebellar ataxias and healthy controls in order to identify disease biomarkers.